After his priestly ordination as a Salesian in Lashio, Shan State on 9 April 1976, he served as a pastor in Loihkam (1976-1981) and Lashio (1981-1983).  From 1983 to 1985, he taught in the seminary of Anisakan.

H.E. Cardinal Bo served as Apostolic Administrator in Lashio from 1985 to 1986 and its Apostolic Prefect from 1986 to 1990.  When the prefecture was elevated to the status of a diocese on 7 July 1990, he was appointed its first bishop.  He was consecrated bishop on 16 December that year.

St. John Paul transferred him to the Diocese of Pathein in Ayeyarwaddy Region on 24 May 1996, but he continued as Apostolic Administrator of Lashio until November 1998.  On 15 May 2003, he was appointed Archbishop of Yangon.  From 2000 to 2006, he headed the Catholic Bishops’ Conference of Myanmar.

H.H. Pope Francis made him Myanmar’s first cardinal at the consistory of 14 February 2015 in the Vatican.   Subsequently, he was appointed a member of the Congregation for Institutes of Consecrated Life and Societies of Apostolic Life, Pontifical Council for Culture, and Secretariat of Communication in the Vatican.

H.E. Cardinal Bo was elected the president of the Federation of Asian Bishops’ Conferences (FABC) on 16 November 2018. FABC brings together 19 bishops’ conferences of Asia as full members and 8 associate members. The federation’s purpose is to foster among its members solidarity and co-responsibility for the welfare of the Church and society in Asia. The decisions of the Federation are without juridical binding force; their acceptance is an expression of collegial responsibility.

Message for Prayers for Myanmar from His Eminence, Charles Cardinal Bo for the CSW65